Effect of charcoal-drug ratio on antidotal efficacy of oral activated charcoal in man.

A Study on the Haemodynamic Interactions between Activated Charcoal and Propranolol/atenolol in Normal Human Subjects.

A random, observer blind, crossover design of study was undertaken in twelve normal male volunteers. Both propranolol (40 mg) and atenolol (50 mg) in single dose oral administration had significantly reduced the heart rate, systolic blood pressure and the value for double product under resting and postexercise conditions compared to the corresponding pretreatment values. Orally administered act...

Comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities

Objective(s): Comparative in vivo studies were carried out to determine the adsorption characteristics of amitriptyline (AMT) on activated charcoal (AC) and sodium polystyrene sulfonate (SPS). AC has been long used as gastric decontamination agent for tricyclic antidepressants and SPS has showed to be highly effective on in-vitro drugs adsorption. Materials and Methods: Sprague-Dawley male rats...

Comparison of Deferoxamine, Activated Charcoal, and Vitamin C in ‎Changing the Serum Level of Fe in Iron Overloaded Rats

Background: Iron is an essential mineral for normal cellular physiology but its ‎overload can lead to cell injury. For many years, deferoxamine injection has been used ‎as an iron chelator for treatment of iron overload. The aim of this study is to compare ‎oral deferoxamine, activated charcoal, and vitamin C, as an absorbent factor of Fe, in ‎changing the serum level of iron in iron overload r...

Commentary: Comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities

The effect of activated charcoal and hyoscine butylbromide alone and in combination on the absorption of mefenamic acid.

Mefenamic acid 500 mg orally was administered to nine healthy volunteers on four occasions 7 days apart. On two occasions allocated at random, activated charcoal (2.5 g of medicoal) was administered 1 h after the drug. Hyoscine butylbromide (20 mg intramuscularly) was given immediately after mefenamic acid on one of these occasions, and on one occasion after mefenamic acid without charcoal. Hyo...